amphotericin B

amphotericin B
(= Fungizone)
Polyene antibiotic from Streptomyces spp. Used as a fungicide, it is cytolytic by causing the formation of pores (5-10 molecules of amphotericin in association with cholesterol) that allow passage of small molecules through the plasma membrane and thus to cytolysis. Only acts on membranes containing sterols (preferentially ergosterol, hence selectivity for fungi). See also filipin.

Dictionary of molecular biology. 2004.

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  • Amphotericin B — Systematic (IUPAC) name (1R,3S,5R,6R,9 …   Wikipedia

  • amphotericin — amphotericin, amphotericin B amphotericin B . 1. an antibiotic and antifungal agent ({C47H73NO17}), produced by a strain of {Streptomyces nodosus}. It is one of a class of polyene macrolide antibiotics effective against fungal infections. It has… …   The Collaborative International Dictionary of English

  • amphotericin B — amphotericin amphotericin, amphotericin B amphotericin B . 1. an antibiotic and antifungal agent ({C47H73NO17}), produced by a strain of {Streptomyces nodosus}. It is one of a class of polyene macrolide antibiotics effective against fungal… …   The Collaborative International Dictionary of English

  • amphotericin B — n the amphotericin that is clinically useful against deep seated and systemic fungal infections * * * am·pho·ter·i·cin B (am″fə terґĭ sin) [USP] one of two polyene antifungal antibiotics (the other, amphotericin A, is not used… …   Medical dictionary

  • amphotericin B — [am΄fə ter′ə sin] n. 〚 AMPHOTERIC + IN1〛 an antibiotic compound, C46H73NO20, used in treating certain diseases caused by parasitic fungi, such as systemic candidiasis * * * …   Universalium

  • amphotericin B — [am΄fə ter′ə sin] n. [ AMPHOTERIC + IN1] an antibiotic compound, C46H73NO20, used in treating certain diseases caused by parasitic fungi, such as systemic candidiasis …   English World dictionary

  • Amphotericin B — Strukturformel Allgemeines Freiname Amphotericin B Andere Namen …   Deutsch Wikipedia

  • amphotericin — am·pho·ter·i·cin .am(p) fə ter ə sən n either of two polyenic antifungal substances obtained from a soil bacterium of the genus Streptomyces (S. nodosus) esp AMPHOTERICIN B * * * n. an antifungal drug that is used to treat deep seated fungal… …   Medical dictionary

  • amphotericin B — noun : the amphotericin that is useful against deep seated and systemic fungal infections …   Useful english dictionary

  • amphotericin B cholesteryl complex — amphotericin B complexed with cholesteryl sulfate in a 1:1 ratio; administered by intravenous infusion in the treatment of disseminated aspergillosis in patients refractory to or intolerant of conventional amphotericin B therapy …   Medical dictionary

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